IBS is a commonly occurring collection of symptoms diagnosed in the world of gastroenterology. It is the most common GI disorder with worldwide prevalence rates ranging from 10-15%. There are between 2.4 and 3.5 million physician visits annually for IBS in the US. Recent research has shown that up to 84% of those with an IBS diagnosis test positive for a Small Intestinal Bacterial Overgrowth breath test.
Breath tests for Small Intestinal Bacterial Overgrowth can be very time consuming for patients, as well as inaccurate, due to many factors.
IBSSureTM is a simple blood test that detects two antibodies which are indicative of bacterial-pathogen-induced motility dysfunction, which can lead to increased incidence of SIBO.
CdtB toxins (cytolethal distending toxin B) are released by gastroenteritis-causing bacteria, against which antibodies are produced by the immune system. These antibodies interact with a protein, vinculin, present in the intestinal cell-lining matrix. This interaction compromises and impairs digestive motility. This pathological breakdown of the gastrointestinal motility complex is foundational to chronic SIBO development and recurrence and has been well-studied and documented.
Not Available in New York state
Only healthcare providers licensed in their state may order laboratory testing.
WHAT IS SIBO?
- Small intestinal bacterial overgrowth (SIBO) is defined as the presence of excessive bacteria in the small intestine
- SIBO is frequently implicated as the cause of chronic diarrhea and malabsorption in addition to intestinal hyper-permeability
- Patients with SIBO may also suffer from unintentional weight loss, nutritional deficiencies, and osteoporosis
- A common misconception is that SIBO affects only a limited number of patients, such as those with an anatomic abnormality of the upper gastrointestinal (GI) tract or those with a motility disorder
- SIBO may be more prevalent than previously thought. This apparent increase in prevalence may have occurred, in part, because readily available diagnostic tests have improved our ability to diagnose SIBO
Symptoms associated with SIBO
- Abdominal pain/discomfort
- Abdominal distension
- Excessive gas
- Fatigue, especially after meals
- Brain fog
- Vitamin and mineral deficiencies
- Worsened symptoms when consuming carbohydrates and fibrous vegetables
- Unexplained weight loss